Goals and Objectives
The UCfC Diabetes Working Group aims to advance understanding of how type 1, type 2, and gestational diabetes impact maternal, fetal, and perinatal outcomes. The group seeks to integrate clinical, glycemic, and psychosocial data across five UC centers to inform evidence-based interventions that optimize maternal health while promoting favorable fetal/neonatal outcomes.
Active Projects
FADED Study: Fatalism and distress: the emotional toll of diabetes in pregnancy
- This is a prospective, longitudinal, survey-based study designed to explore the emotional and behavioral impacts of having diabetes in pregnancy. Specifically, the goal is to evaluate the level of health fatalism and diabetes distress across pregnancy and postpartum in people with type 1 diabetes (T1D), type 2 diabetes (T2D), or gestational diabetes (GD) will fill out multiple surveys across pregnancy and after delivery
POSTPOD Trial: Postpartum Continuous Glucose Monitoring for Type 2 Diabetes Mellitus Risk Evaluation in Patients with Gestational Diabetes Mellitus:
- This is a pilot study designed to evaluate the effectiveness of continuous glucose monitoring (CGM) within hours of delivery to predict long-term risk of Type 2 Diabetes Mellitus in patients diagnosed with gestational diabetes.
AIMING RCT: Automated Insulin Delivery for Management of Intrapartum Glycemic
- This is a randomized controlled trial designed to evaluate if automated insulin delivery (AID) systems can be used for glucose management during labor/delivery for pregnant people with type 1 diabetes (T1D). The study aims to understand neonatal outcomes, birth satisfaction, and glycemic parameters associated with intrapartum use of AID systems compared with intrapartum intravenous (IV) insulin, which is the current standard of care.
COSCLIP Study: Commercial or Open-Source Closed Loop Impact on Pregnancy
- This is a prospective, longitudinal, observational study designed to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The goal is to compare pregnant people who use commercial AID systems and pregnant people who use open-source AID systems to see if clinical, glycemic, and/or behavioral outcomes are different with these different types of systems.
Publications
- Sobhani NC, Goemans S, Nguyen A, et al. Continuous glucose monitoring in pregnancies with type 1 diabetes: small increases in time-in-range improve maternal and perinatal outcomes. Am J Obstet Gynecol. 2024;231(4):467.e1-467.e8. doi:10.1016/j.ajog.2024.01.010
- Sobhani NC, Han CS, Sarker MR, Shah S, Ramos GA. Use of a Commercially Available Automated Insulin Delivery System for the Management of Type 1 Diabetes in Pregnancy. J Diabetes Sci Technol. 2024;18(6):1509-1510. doi:10.1177/19322968241279569
- Shao SJ, Kent M, Koenig JB, Kaplan ML, Rogerson D, Shuman G, Bergam B, Ramos GA, Han CS, Sobhani NC. Accuracy of a model for predicting primary cesarean delivery in pregnancies complicated by gestational diabetes mellitus in a multicenter external population. Am J Obstet Gynecol MFM. 2024;6(12):101538. doi:10.1016/j.ajogmf.2024.101538
Presentations
- Richley M, Fung K, Oakes MC, Nguyen A, Murphy AM, Mok T, Lester J, Kwan L, Demirjian M, Gerl R, Levin-Lopez D, Freeby M, Sherman-Brown A, Chung JH, Han CS. A randomized controlled trial of detemir vs NPH in gestational and type 2 diabetes: DETERMINE study. Poster presentation at SMFM Annual Pregnancy Meeting (2025).
- Adkins S, Verduzco I, Dzyuba B, Diala PC, Goemans S, Nguyen Antoinette, Fitzgerald K, Chambers ME, Richley M, Gabby LC, Field N, Han CS, Ramos GA, Sobhani NC. Mean glucose and standard deviation on continuous glucose monitoring for type 1 diabetes and perinatal outcomes. Poster presentation at SMFM Annual Pregnancy Meeting (2026).
- Verduzco I, Zhou A, Diala P, Dzyuba B, Santoso N, Han CS, Ramos GA, Kohn MA, Sobhani NC. Intrapartum continuous glucose monitor metrics and neonatal hypoglycemia. Poster presentation at SRI 73rd Annual Meeting (2026).
- Dzyuba B, Adkins S, Verduzco I, Zhou A, Diala P, Santoso N, Han CS, Kohn MA, Sobhani NC, Ramos GA. Concordance between continuous glucose monitors versus capillary blood glucose values during labor in individuals with type 1 diabetes. Poster presentation at SRI 73rd Annual Meeting (2026).
Members
Nancy Field (UC Davis)
Judith Chung (UC Irvine)
Christina Han (UC Los Angeles)
Kimberly Huynh (UC Los Angeles)
Sandy Ramos (UC San Diego)
Erin Gallent (UC San Diego)
Nasim Sobhani (UC San Francisco)
Ivonne Verduzco (UC San Francisco)
Students
Rujuta Sathe (UC Los Angeles)